Curated Information
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Curated Information Page
PubMed Id: 20178741 
Li W, et al. (2010) Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 140, 477-90 20178741
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S63-p - Jun (human)
Orthologous residues
Jun (human): S63‑p, Jun (mouse): S63‑p, Jun (rat): S63‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-10A (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human

S518-p - Merlin (human)
Orthologous residues
Merlin (human): S518‑p, Merlin (mouse): S518‑p, Merlin (rat): S514‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DDB1 (human) Disrupts co-immunoprecipitation
VPRBP (human) Disrupts co-immunoprecipitation
 Comments:  phosphorylated merlin in non-nuclear fractions, unphosphorylated merlin localized in nucleus.

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