Curated Information
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Curated Information Page
PubMed Id: 20303298 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Nava P, et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402 20303298
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T308-p - Akt1 (human) ▲
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  T84 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-gamma increase 5 hr
TNF increase
TNF IFN-gamma augment treatment-induced increase
IFN-gamma increase 72 hr
TNF increase slight increase
TNF IFN-gamma no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered

S552-p - CTNNB1 (human) ▲
Orthologous residues
CTNNB1 (human): S552‑p, CTNNB1 (mouse): S552‑p, CTNNB1 (rat): S552‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  T84 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-gamma increase 5 hr
TNF increase
TNF IFN-gamma augment treatment-induced increase

S1490-p - LRP6 (human) ▲
Orthologous residues
LRP6 (human): S1490‑p, LRP6 (mouse): S1490‑p, LRP6 (rat): ‑
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  T84 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-gamma increase 5 hr treatment
TNF increase
TNF IFN-gamma no effect upon treatment-induced increase
IFN-gamma decrease 72 hr
TNF increase
TNF IFN-gamma no effect upon treatment-induced decrease

T308-p - Akt1 (mouse) ▲
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  epithelial
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  intestinal epithelial cells
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
inflammation increase dextran sulfate sodium
IL-6 no change compared to control
IL-22 no change compared to control
inflammation increase dextran sulfate sodium
tricibine no change compared to control
tricibine inflammation inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered

S552-p - CTNNB1 (mouse) ▲
Orthologous residues
CTNNB1 (human): S552‑p, CTNNB1 (mouse): S552‑p, CTNNB1 (rat): S552‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  epithelial
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  intestinal epithelial cells
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
inflammation increase dextran sulfate sodium
IL-6 no change compared to control
IL-22 no change compared to control
inflammation increase dextran sulfate sodium
tricibine no change compared to control
tricibine inflammation inhibit treatment-induced increase
IFNG (mouse) increase dextran sulfate sodium, IFNG -/- decreases

S9-p - GSK3B (mouse) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  epithelial
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  intestinal epithelial cells
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
inflammation increase dextran sulfate sodium
IL-6 no change compared to control
IL-22 no change compared to control

S1490-p - LRP6 (mouse) ▲
Orthologous residues
LRP6 (human): S1490‑p, LRP6 (mouse): S1490‑p, LRP6 (rat): ‑
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  epithelial
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  intestinal epithelial cells


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