|
Orthologous residues
|
|
DDX58 (human): S8‑p, DDX58 (mouse): N8‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
|
|
Disease tissue studied:
lung cancer
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial), A459, HeLa (cervical)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
calyculin A
|
|
|
|
increase
|
|
|
IFN-beta
|
|
|
|
decrease
|
|
|
virus infection
|
|
|
|
decrease
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization, molecular association, regulation, ubiquitination
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
MAVS (human)
|
|
Disrupts
|
|
|
co-immunoprecipitation
|
|
TRIM25 (human)
|
|
Disrupts
|
|
|
co-immunoprecipitation
|
|
