Curated Information
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Curated Information Page
PubMed Id: 20205385 
Jin LL, et al. (2010) Measurement of protein phosphorylation stoichiometry by selected reaction monitoring mass spectrometry. J Proteome Res 9, 2752-61 20205385
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y194-p - Lyn (human)
Orthologous residues
Lyn (human): Y194‑p, Lyn iso2 (human): Y173‑p, Lyn (mouse): Y194‑p, Lyn iso2 (mouse): Y173‑p, Lyn (rat): Y194‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  293T (epithelial), KMS-11 (B lymphocyte), KMS-12
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase

Y397-p - Lyn (human)
Orthologous residues
Lyn (human): Y397‑p, Lyn iso2 (human): Y376‑p, Lyn (mouse): Y397‑p, Lyn iso2 (mouse): Y376‑p, Lyn (rat): Y397‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  293T (epithelial), KMS-11 (B lymphocyte), KMS-12
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase


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