Curated Information
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Curated Information Page
PubMed Id: 7525290 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Berling B, et al. (1994) Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro. Eur J Cell Biol 64, 120-30 7525290
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S136-p - MAP2 (rat) ▲
Orthologous residues
MAP2 (human): S136‑p, MAP2 iso2 (human): S136‑p, MAP2 iso3 (human): S136‑p, MAP2 iso4 (human): S136‑p, MAP2 (mouse): S136‑p, MAP2 iso2 (mouse): S136‑p, MAP2 iso6 (mouse): S136‑p, MAP2 (rat): S136‑p, MAP2 iso2 (rat): S136‑p, MAP2 iso3 (rat): S136‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), PtK2 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey, mouse, potoroo
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE GSK3A (rat)
KINASE CDK2 (human)
KINASE CDK5 (rat)
KINASE ERK1 (rat)

S136-p - MAP2 iso2 (rat) ▲
Orthologous residues
MAP2 (human): S136‑p, MAP2 iso2 (human): S136‑p, MAP2 iso3 (human): S136‑p, MAP2 iso4 (human): S136‑p, MAP2 (mouse): S136‑p, MAP2 iso2 (mouse): S136‑p, MAP2 iso6 (mouse): S136‑p, MAP2 (rat): S136‑p, MAP2 iso2 (rat): S136‑p, MAP2 iso3 (rat): S136‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), PtK2 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey, mouse, potoroo
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (rat)
KINASE GSK3A (rat)
KINASE CDK2 (human)
KINASE ERK1 (rat)

S136-p - MAP2 iso3 (rat) ▲
Orthologous residues
MAP2 (human): S136‑p, MAP2 iso2 (human): S136‑p, MAP2 iso3 (human): S136‑p, MAP2 iso4 (human): S136‑p, MAP2 (mouse): S136‑p, MAP2 iso2 (mouse): S136‑p, MAP2 iso6 (mouse): S136‑p, MAP2 (rat): S136‑p, MAP2 iso2 (rat): S136‑p, MAP2 iso3 (rat): S136‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), PtK2 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey, mouse, potoroo
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE ERK1 (rat)
KINASE CDK2 (human)
KINASE CDK5 (rat)
KINASE GSK3A (rat)


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