Curated Information
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Curated Information Page
PubMed Id: 11726515 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li S, Couvillon AD, Brasher BB, Van Etten RA (2001) Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. EMBO J 20, 6793-804 11726515
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Y209-p - Grb2 (human)
Orthologous residues
Grb2 (human): Y209‑p, Grb2 iso2 (human): Y168‑p, Grb2 (mouse): Y209‑p, Grb2 (rat): Y209‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  293T (epithelial), A431 (epithelial), BaF3 ('B lymphocyte, precursor'), K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Bcr/Abl (human) genetic transfer of constitutively active upstream enzyme, mutation in upstream enzyme recognition motif, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOS1 (human) SH3_1 Disrupts


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