|
Orthologous residues
|
|
p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
B lymphocyte-spleen [p53 (mouse), transgenic]
|
|
Cellular systems studied:
primary cultured cells
|
|
Species studied:
mouse
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
ionizing radiation
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
apoptosis, altered, carcinogenesis, inhibited
|
|
Comments:
suppresses tumorogenesis
|
|
Associated Diseases
|
|
Diseases:
|
Alterations:
|
Comments:
|
|
non-Hodgkin's lymphoma
|
decreased
|
|
|
