|
Orthologous residues
|
|
SHP‑2 (human): Y546‑p, SHP‑2 (mouse): Y546‑p, SHP‑2 (rat): Y546‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
REF52 (fibroblast)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
rat
|
|
Downstream Regulation
|
|
Effect of modification (function):
enzymatic activity, induced, molecular association, regulation
|
|
Effect of modification (process):
transcription, altered
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
SHP-2 (human)
|
SH2
|
Induces
|
|
|
in vitro, functional assay
|
|
Grb2 (human)
|
|
Not reported
|
|
|
pull-down assay
|
|
