Curated Information
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Curated Information Page
PubMed Id: 11684012 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lu W, Gong D, Bar-Sagi D, Cole PA (2001) Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell 8, 759-69 11684012
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y546-p - SHP-2 (human)
Orthologous residues
SHP‑2 (human): Y546‑p, SHP‑2 iso2 (human): Y542‑p, SHP‑2 (mouse): Y546‑p, SHP‑2 (rat): Y546‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  REF52 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  rat
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) SH2 Induces functional assay, in vitro
Grb2 (human) Not reported pull-down assay

Y584-p - SHP-2 (human)
Orthologous residues
SHP‑2 (human): Y584‑p, SHP‑2 iso2 (human): Y580‑p, SHP‑2 (mouse): Y584‑p, SHP‑2 (rat): Y584‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  REF52 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  rat
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) SH2 Induces functional assay, in vitro


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