Curated Information
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Curated Information Page
PubMed Id: 9632781 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hadari YR, Kouhara H, Lax I, Schlessinger J (1998) Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol 18, 3966-73 9632781
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y196-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y196‑p, FRS2 (mouse): Y196‑p, FRS2 (rat): Y196‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF1 increase

Y306-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y306‑p, FRS2 (mouse): Y306‑p, FRS2 (rat): Y306‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF1 increase

Y349-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y349‑p, FRS2 (mouse): Y349‑p, FRS2 (rat): Y349‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF1 increase

Y392-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y392‑p, FRS2 (mouse): Y392‑p, FRS2 (rat): Y392‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF1 increase

Y436-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y436‑p, FRS2 (mouse): Y436‑p, FRS2 (rat): Y436‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
FGF1 increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (mouse) Induces activity, induced co-immunoprecipitation, electrophoretic visualization

Y471-p - FRS2 (mouse)
Orthologous residues
FRS2 (human): Y471‑p, FRS2 (mouse): Y471‑p, FRS2 (rat): Y471‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (mouse) Not reported


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