Curated Information
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Curated Information Page
PubMed Id: 12172553 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Inoki K, et al. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-57 12172553
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S939-p - TSC2 (rat)
Orthologous residues
TSC2 (human): S939‑p, TSC2 iso3 (human): S939‑p, TSC2 iso4 (human): S939‑p, TSC2 (mouse): S939‑p, TSC2 iso6 (mouse): S939‑p, TSC2 (rat): S939‑p, TSC2 iso2 (rat): S939‑p

S1130-p - TSC2 (rat)
Orthologous residues
TSC2 (human): S1130‑p, TSC2 iso3 (human): S1086‑p, TSC2 iso4 (human): S1130‑p, TSC2 (mouse): S1130‑p, TSC2 iso6 (mouse): S1130‑p, TSC2 (rat): S1130‑p, TSC2 iso2 (rat): S1087‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC2 iso2 (rat)]
 Comments:  The authors used rat tuberin isoform 2 (SP# P49816-2) to characterize the phosphorylation sites.
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

S1132-p - TSC2 (rat)
Orthologous residues
TSC2 (human): S1132‑p, TSC2 iso3 (human): S1088‑p, TSC2 iso4 (human): S1132‑p, TSC2 (mouse): S1132‑p, TSC2 iso6 (mouse): S1132‑p, TSC2 (rat): S1132‑p, TSC2 iso2 (rat): S1089‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC2 iso2 (rat)]
 Comments:  The authors used rat tuberin isoform 2 (SP# P49816-2) to characterize the phosphorylation sites.
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

T1466-p - TSC2 (rat)
Orthologous residues
TSC2 (human): T1462‑p, TSC2 iso3 (human): T1418‑p, TSC2 iso4 (human): T1439‑p, TSC2 (mouse): T1465‑p, TSC2 iso6 (mouse): T1443‑p, TSC2 (rat): T1466‑p, TSC2 iso2 (rat): T1423‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC2 iso2 (rat)]
 Comments:  The authors used rat tuberin isoform 2 (SP# P49816-2) to characterize the phosphorylation sites.
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

S939-p - TSC2 iso2 (rat)
Orthologous residues
TSC2 (human): S939‑p, TSC2 iso3 (human): S939‑p, TSC2 iso4 (human): S939‑p, TSC2 (mouse): S939‑p, TSC2 iso6 (mouse): S939‑p, TSC2 (rat): S939‑p, TSC2 iso2 (rat): S939‑p

S1087-p - TSC2 iso2 (rat)
Orthologous residues
TSC2 (human): S1130‑p, TSC2 iso3 (human): S1086‑p, TSC2 iso4 (human): S1130‑p, TSC2 (mouse): S1130‑p, TSC2 iso6 (mouse): S1130‑p, TSC2 (rat): S1130‑p, TSC2 iso2 (rat): S1087‑p

S1089-p - TSC2 iso2 (rat)
Orthologous residues
TSC2 (human): S1132‑p, TSC2 iso3 (human): S1088‑p, TSC2 iso4 (human): S1132‑p, TSC2 (mouse): S1132‑p, TSC2 iso6 (mouse): S1132‑p, TSC2 (rat): S1132‑p, TSC2 iso2 (rat): S1089‑p

T1423-p - TSC2 iso2 (rat)
Orthologous residues
TSC2 (human): T1462‑p, TSC2 iso3 (human): T1418‑p, TSC2 iso4 (human): T1439‑p, TSC2 (mouse): T1465‑p, TSC2 iso6 (mouse): T1443‑p, TSC2 (rat): T1466‑p, TSC2 iso2 (rat): T1423‑p


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