Curated Information
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Curated Information Page
PubMed Id: 20229236 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Keller-Pinter A, et al. (2010) Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner. Cell Mol Life Sci 67, 1881-94 20229236
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S179-p - syndecan-4 (human)
Orthologous residues
syndecan‑4 (human): S179‑p, syndecan‑4 (mouse): S179‑p, syndecan‑4 (rat): S183‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, protein processing
 Effect of modification (process):  cell cycle regulation, cytoskeletal reorganization
 Comments:  S179A mutant abrogates protein shedding


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