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Orthologous residues
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syndecan‑4 (human): S179‑p, syndecan‑4 (mouse): S179‑p, syndecan‑4 (rat): S183‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody, western blotting
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Disease tissue studied:
breast cancer
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Relevant cell lines - cell types - tissues:
MCF-7 (breast cell)
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Cellular systems studied:
cell lines
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Species studied:
human
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Downstream Regulation
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Effect of modification (function):
intracellular localization, protein processing
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Effect of modification (process):
cell cycle regulation, cytoskeletal reorganization
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Comments:
S179A mutant abrogates protein shedding
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