Curated Information

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Curated Information Page

PubMed Id: 20096447

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Yuan J, et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140, 384-96 20096447

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T42-p - USP10 (human)

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Orthologous residues

USP10 (human): T42‑p, USP10 (mouse): I41‑p, USP10 (rat): I41‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Disease tissue studied: colorectal cancer, colorectal carcinoma, kidney cancer

Relevant cell lines - cell types - tissues: HCT116 (intestinal), kidney

Cellular systems studied: cell lines, tissue

Species studied: human

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ATM (human)	modification site within consensus motif, pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase
KU-55933	ionizing radiation			inhibit treatment-induced increase

Downstream Regulation

Effect of modification (function): intracellular localization, protein stabilization, ubiquitination

Effect of modification (process): carcinogenesis, inhibited, cell growth, altered

Comments: regulates p53 homeostasis

S337-p - USP10 (human)

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