Curated Information
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Curated Information Page
PubMed Id: 20194499 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Malhotra R, et al. (2010) G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J Biol Chem 285, 13748-60 20194499
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S29-p - GRK2 (rat)
Orthologous residues
GRK2 (human): S29‑p, GRK2 (mouse): S29‑p, GRK2 (rat): S29‑p, GRK2 (cow): S29‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (mouse) activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
angiotensin 2 increase
mechanical stress increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, intracellular localization


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