|
Orthologous residues
|
|
Nur77 (human): S351‑p, Nur77 (mouse): S354‑p, Nur77 (rat): S350‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
electrophoretic mobility shift, mutation of modification site, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial) [Akt1 (human)], 293T (epithelial) [Nur77 (rat)]
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Akt1 (human)
|
transfection of constitutively active enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Effect of modification (process):
apoptosis, inhibited
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
14-3-3 beta (rat)
|
|
Induces
|
|
|
co-immunoprecipitation
|
|
