Curated Information
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Curated Information Page
PubMed Id: 11970865 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Impey S, et al. (2002) Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron 34, 235-44 11970865
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S301-p - CBP (mouse)
Orthologous residues
CBP (human): S302‑p, CBP (mouse): S301‑p, CBP (rat): S301‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  primary cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CaMK4 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CaMK4 (human) pharmacological inhibitor of upstream enzyme, genetic transfer of dominant-negative enzyme, genetic transfer of constitutively active upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA increase
KN-93 NMDA inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, induced

S301-p - CBP (rat)
Orthologous residues
CBP (human): S302‑p, CBP (mouse): S301‑p, CBP (rat): S301‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  primary cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CaMK4 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CaMK4 (human) pharmacological inhibitor of upstream enzyme, genetic transfer of dominant-negative enzyme, genetic transfer of constitutively active upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA increase
KN-93 NMDA inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, induced


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