Curated Information

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Curated Information Page

PubMed Id: 11970865

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Impey S, et al. (2002) Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron 34, 235-44 11970865

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S301-p - CBP (mouse)

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Orthologous residues

CBP (human): S302‑p, CBP (mouse): S301‑p, CBP (rat): S301‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cells

Species studied: rat

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CaMK4 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CaMK4 (human)	genetic transfer of constitutively active upstream enzyme, pharmacological inhibitor of upstream enzyme, genetic transfer of dominant-negative enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
NMDA				increase
KN-93	NMDA			inhibit treatment-induced increase

Downstream Regulation

Effect of modification (process): transcription, altered

S301-p - CBP (rat)

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