Curated Information
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PubMed Id: 20110615 
Tremblay MA, Acker CM, Davies P (2010) Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. J Alzheimers Dis 19, 721-33 20110615
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y197-p - Tau iso8 (human)
Orthologous residues
Tau (human): Y514‑p, Tau iso2 (human): Y139‑p, Tau iso3 (human): Y103‑p, Tau iso5 (human): Y197‑p, Tau iso6 (human): Y139‑p, Tau iso7 (human): Y168‑p, Tau iso8 (human): Y197‑p, Tau (mouse): Y489‑p, Tau iso3 (mouse): Y186‑p, Tau iso7 (mouse): Y146‑p, Tau (rat): Y508‑p, Tau (cow): Y204‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  brain cancer, glioma
 Relevant cell lines - cell types - tissues:  U138 (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Arg (human) transfection of wild-type enzyme, mutation in upstream enzyme recognition motif

Y310-p - Tau iso8 (human)
Orthologous residues
Tau (human): Y627‑p, Tau iso2 (human): Y221‑p, Tau iso3 (human): Y185‑p, Tau iso5 (human): Y279‑p, Tau iso6 (human): Y252‑p, Tau iso7 (human): Y281‑p, Tau iso8 (human): Y310‑p, Tau (mouse): Y602‑p, Tau iso3 (mouse): Y299‑p, Tau iso7 (mouse): Y259‑p, Tau (rat): Y621‑p, Tau (cow): Y317‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  brain cancer, glioma
 Relevant cell lines - cell types - tissues:  U138 (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Arg (human) transfection of wild-type enzyme, mutation in upstream enzyme recognition motif

Y394-p - Tau iso8 (human)
Orthologous residues
Tau (human): Y711‑p, Tau iso2 (human): Y305‑p, Tau iso3 (human): Y269‑p, Tau iso5 (human): Y363‑p, Tau iso6 (human): Y336‑p, Tau iso7 (human): Y365‑p, Tau iso8 (human): Y394‑p, Tau (mouse): Y686‑p, Tau iso3 (mouse): Y383‑p, Tau iso7 (mouse): Y343‑p, Tau (rat): Y705‑p, Tau (cow): Y401‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  Alzheimer's disease, brain cancer, glioma
 Relevant cell lines - cell types - tissues:  neuron-'brain, hippocampus', U138 (glial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Arg (human) transfection of wild-type enzyme, mutation in upstream enzyme recognition motif
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S396-p - Tau iso8 (human)
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  neuron-'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased


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