Curated Information

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PubMed Id: 20089902

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Loweth JA, et al. (2010) Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine. J Neurosci 30, 939-49 20089902

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S142-p - CREB (rat)

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Orthologous residues

CREB (human): S142‑p, CREB iso2 (human): S128‑p, CREB (mouse): S142‑p, CREB (rat): S142‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, nucleus accumbens'

Cellular systems studied: tissue

Species studied: rat

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CaMK2-alpha (rat)	transfection of wild-type enzyme

S849-p - GluR1 (rat)

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Orthologous residues

GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, nucleus accumbens'

Cellular systems studied: tissue

Species studied: rat

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CaMK2-alpha (rat)	transfection of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
amphetamine				increase	increase in nucleus accumbens shell at 4 days, but not 2-3 weeks, post-treatment. No increase in core

S863-p - GluR1 (rat)

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Orthologous residues

GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, nucleus accumbens'

Cellular systems studied: tissue

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
amphetamine				increase	increase in nucleus accumbens shell, but not core

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