Curated Information

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Curated Information Page

PubMed Id: 9520446

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Ling L, Cao Z, Goeddel DV (1998) NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A 95, 3792-7 9520446

S176-p - IKK-alpha (human)

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Orthologous residues

IKK‑alpha (human): S176‑p, IKK‑alpha (mouse): S176‑p, IKK‑alpha (rat): S176‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Nik (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Nik (human)	transfection of wild-type enzyme

Downstream Regulation

Effect of modification (function): enzymatic activity, induced

Comments: S176A mutant acts as dominant negative inhibitor of cytokine-mediated NFkB activation.

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