Curated Information

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PubMed Id: 12138205

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kane LP, et al. (2002) Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22, 5962-74 12138205

S400-p - Cot (human)

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Orthologous residues

Cot (human): S400‑p, Cot (mouse): S400‑p, Cot (rat): S400‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping

Relevant cell lines - cell types - tissues: Jurkat (T lymphocyte)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Akt1 (human)

Downstream Regulation

Effect of modification (process): transcription, altered

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