Curated Information
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PubMed Id: 8384556 
Obermeier A, et al. (1993) Tyrosine 785 is a major determinant of Trk--substrate interaction. EMBO J 12, 933-41 8384556
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y791-p - TrkA (human)
Orthologous residues
TrkA (human): Y791‑p, TrkA iso2 (human): Y785‑p, TrkA (mouse): Y794‑p, TrkA (rat): Y794‑p, TrkA iso2 (rat): Y788‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  adrenal cancer, pheochromocytoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF augment treatment-induced increase
vanadate increase
NGF vanadate augment treatment-induced increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (human) Induces phosphorylation in vitro, co-immunoprecipitation, sequence-specific competitor
 Comments:  association in vitro and in vivo

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