Curated Information
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PubMed Id: 12387894 
Liu F, Iqbal K, Grundke-Iqbal I, Gong CX (2002) Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett 530, 209-14 12387894
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T181-p - Tau iso8 (human)
Orthologous residues
Tau (human): T498‑p, Tau iso2 (human): T123‑p, Tau iso3 (human): T87‑p, Tau iso5 (human): T181‑p, Tau iso6 (human): T123‑p, Tau iso7 (human): T152‑p, Tau iso8 (human): T181‑p, Tau (mouse): T473‑p, Tau iso3 (mouse): T170‑p, Tau iso7 (mouse): T112‑p, Tau (rat): T492‑p, Tau (cow): T172‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to T181 in the numbering of the brain Tau isoform in this paper

S199-p - Tau iso8 (human)
Orthologous residues
Tau (human): S516‑p, Tau iso2 (human): S141‑p, Tau iso3 (human): S105‑p, Tau iso5 (human): S199‑p, Tau iso6 (human): S141‑p, Tau iso7 (human): S170‑p, Tau iso8 (human): S199‑p, Tau (mouse): S491‑p, Tau iso3 (mouse): S188‑p, Tau iso7 (mouse): S148‑p, Tau (rat): S510‑p, Tau (cow): S206‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to S199 in the numbering of the brain Tau isoform in this paper

S202-p - Tau iso8 (human)
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to S202 in the numbering of the brain Tau isoform in this paper

T205-p - Tau iso8 (human)
Orthologous residues
Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
KINASE GSK3B (human)
 Comments:  Corresponds to T205 in the numbering of the brain Tau isoform in this paper

T212-p - Tau iso8 (human)
Orthologous residues
Tau (human): T529‑p, Tau iso2 (human): T154‑p, Tau iso3 (human): T118‑p, Tau iso5 (human): T212‑p, Tau iso6 (human): T154‑p, Tau iso7 (human): T183‑p, Tau iso8 (human): T212‑p, Tau (mouse): T504‑p, Tau iso3 (mouse): T201‑p, Tau iso7 (mouse): T161‑p, Tau (rat): T523‑p, Tau (cow): T219‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to T212 in the numbering of the brain Tau isoform in this paper

S214-p - Tau iso8 (human)
Orthologous residues
Tau (human): S531‑p, Tau iso2 (human): S156‑p, Tau iso3 (human): S120‑p, Tau iso5 (human): S214‑p, Tau iso6 (human): S156‑p, Tau iso7 (human): S185‑p, Tau iso8 (human): S214‑p, Tau (mouse): S506‑p, Tau iso3 (mouse): S203‑p, Tau iso7 (mouse): S163‑p, Tau (rat): S525‑p, Tau (cow): S221‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to S214 in the numbering of the brain Tau isoform in this paper

T217-p - Tau iso8 (human)
Orthologous residues
Tau (human): T534‑p, Tau iso2 (human): T159‑p, Tau iso3 (human): T123‑p, Tau iso5 (human): T217‑p, Tau iso6 (human): T159‑p, Tau iso7 (human): T188‑p, Tau iso8 (human): T217‑p, Tau (mouse): T509‑p, Tau iso3 (mouse): T206‑p, Tau iso7 (mouse): T166‑p, Tau (rat): T528‑p, Tau (cow): T224‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to T217 in the numbering of the brain Tau isoform in this paper

T231-p - Tau iso8 (human)
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
KINASE CDK5 (human)
 Comments:  Corresponds to T231 in the numbering of the brain Tau isoform in this paper

S235-p - Tau iso8 (human)
Orthologous residues
Tau (human): S552‑p, Tau iso2 (human): S177‑p, Tau iso3 (human): S141‑p, Tau iso5 (human): S235‑p, Tau iso6 (human): S177‑p, Tau iso7 (human): S206‑p, Tau iso8 (human): S235‑p, Tau (mouse): S527‑p, Tau iso3 (mouse): S224‑p, Tau iso7 (mouse): S184‑p, Tau (rat): S546‑p, Tau (cow): S242‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
 Comments:  Corresponds to S235 in the numbering of the brain Tau isoform in this paper

S396-p - Tau iso8 (human)
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
KINASE GSK3B (human)
 Comments:  Corresponds to S396 in the numbering of the brain Tau isoform in this paper

S404-p - Tau iso8 (human)
Orthologous residues
Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
KINASE GSK3B (human)
 Comments:  Corresponds to S404 in the numbering of the brain Tau isoform in this paper


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