Curated Information
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Curated Information Page
PubMed Id: 8197134 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Improta T, et al. (1994) Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc Natl Acad Sci U S A 91, 4776-80 8197134
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y701-p - STAT1 (human)
Orthologous residues
STAT1 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  fibrosarcoma of soft tissue
 Relevant cell lines - cell types - tissues:  2fTGH (fibroblast), U3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-alpha increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
STAT2 (human) Induces co-immunoprecipitation

Y690-p - STAT2 (human)
Orthologous residues
STAT2 (human): Y690‑p, STAT2 (mouse): Y689‑p, STAT2 iso3 (mouse): Y688‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, peptide sequencing, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  fibrosarcoma of soft tissue
 Relevant cell lines - cell types - tissues:  2fTGH (fibroblast), U3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Lck (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-alpha increase


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