Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 10748192 
Gamero AM, Larner AC (2000) Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727. J Biol Chem 275, 16574-8 10748192
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y701-p - STAT1 (human)
Orthologous residues
STAT1 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-alpha increase
anti-CD3 no change compared to control

S727-p - STAT1 (human)
Orthologous residues
STAT1 (human): S727‑p, STAT1 (mouse): S727‑p, STAT1 (rat): S727‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
PP1 anti-CD3 inhibit treatment-induced increase
PD98059 anti-CD3 no effect upon treatment-induced increase
U0126 anti-CD3 no effect upon treatment-induced increase
H-7 anti-CD3 no effect upon treatment-induced increase
SB203580 anti-CD3 no effect upon treatment-induced increase
LY294002 anti-CD3 no effect upon treatment-induced increase
wortmannin anti-CD3 no effect upon treatment-induced increase
anti-CD28 anti-CD3 no effect upon treatment-induced increase


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.