Curated Information
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Curated Information Page
PubMed Id: 20188673 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Xu P, Derynck R (2010) Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell 37, 551-66 20188673
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T735-p - TACE (human)
Orthologous residues
TACE (human): T735‑p, TACE (mouse): T735‑p, TACE (rat): T735‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), T4-2
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE P38A (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
SB203580 anisomycin inhibit treatment-induced increase
siRNA anisomycin inhibit treatment-induced increase p38 MAPK alpha siRNA
IL-1b increase
siRNA anisomycin inhibit treatment-induced increase p38 MAPK alpha siRNA
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, intracellular localization
 Effect of modification (process):  cell cycle regulation

S791-p - TACE (human)
Orthologous residues
TACE (human): S791‑p, TACE (mouse): S794‑p, TACE (rat): S794‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), T4-2
 Cellular systems studied:  cell lines
 Species studied:  hamster, human

S819-p - TACE (human)
Orthologous residues
TACE (human): S819‑p, TACE (mouse): S822‑p, TACE (rat): S822‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), T4-2
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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