|
Orthologous residues
|
|
hnRNP E1 (human): S43‑p, hnRNP E1 (mouse): S43‑p, hnRNP E1 (rat): S200‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
NMuMG (epithelial)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Akt2 (human)
|
activation of upstream enzyme, pharmacological inhibitor of upstream enzyme, modification site within consensus motif, pharmacological activator of upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
TGF-beta
|
|
|
|
increase
|
|
|
LY294002
|
TGF-beta
|
|
|
inhibit treatment-induced increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
translation, altered
|
