Curated Information
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Curated Information Page
PubMed Id: 19609947 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bai D, Ueno L, Vogt PK (2009) Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int J Cancer 125, 2863-70 19609947
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S65-p - 4E-BP1 (human)
Orthologous residues
4E‑BP1 (human): S65‑p, 4E‑BP1 (mouse): S64‑p, 4E‑BP1 (rat): S64‑p, 4E‑BP1 (fruit fly): S65‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken

T308-p - Akt1 (human)
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

T23-p - IKKA (human)
Orthologous residues
IKKA (human): T23‑p, IKKA (mouse): T23‑p, IKKA (rat): T23‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S534-p - NFkB-p65 (mouse)
Orthologous residues
NFkB‑p65 (human): S536‑p, NFkB‑p65 (mouse): S534‑p, NFkB‑p65 (rat): S535‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IKKA (human)
KINASE IKKB (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKA (human) mutation in upstream enzyme recognition motif, transfection of wild-type enzyme, transfection of dominant-negative enzyme
KINASE IKKB (human) mutation in upstream enzyme recognition motif, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Akt1 (human) increase
Downstream Regulation
 Effect of modification (function):  activity, induced
 Effect of modification (process):  carcinogenesis, induced, transcription, induced


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