Curated Information
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Curated Information Page
PubMed Id: 20001970 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
O'Shea JM, Perkins ND (2010) Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation. Biochem J 426, 345-54 20001970
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T435-p - NFkB-p65 (human)
Orthologous residues
NFkB‑p65 (human): T435‑p, NFkB‑p65 (mouse): T433‑p, NFkB‑p65 (rat): T434‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [homozygous knockout], U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
calyculin A increase
TNF increase
Downstream Regulation
 Effect of modification (process):  transcription, inhibited


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