Curated Information
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Curated Information Page
PubMed Id: 9230306 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rochette-Egly C, et al. (1997) Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90, 97-107 9230306
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S77-p - RARA (mouse) ▲
Orthologous residues
RARA (human): S77‑p, RARA (mouse): S77‑p, RARA (rat): S74‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, immunoprecipitation, mutation of modification site, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)
KINASE CDK7 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK7 (human) co-immunoprecipitation, 2D analysis, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  transcription, altered

S445-p - RARA (mouse) ▲
Orthologous residues
RARA (human): S445‑p, RARA (mouse): S445‑p, RARA (rat): S442‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey

S449-p - RARA (mouse) ▲
Orthologous residues
RARA (human): S449‑p, RARA (mouse): S449‑p, RARA (rat): S446‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey

S456-p - RARA (mouse) ▲
Orthologous residues
RARA (human): S456‑p, RARA (mouse): S456‑p, RARA (rat): S453‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey

S461-p - RARA (mouse) ▲
Orthologous residues
RARA (human): S461‑p, RARA (mouse): S461‑p, RARA (rat): S458‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK1 (human)
KINASE CDK7 (human)


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