Curated Information
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Curated Information Page
PubMed Id: 12725730 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yamanaka T, et al. (2003) Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol 13, 734-43 12725730
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S663-p - LLGL1 (human) ▲
Orthologous residues
LLGL1 (human): S663‑p, LLGL1 (mouse): S662‑p, LLGL1 (rat): S662‑p
Characterization
 Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCI (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (mouse) transfection of inactive enzyme, co-immunoprecipitation, phospho-antibody, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  localization to cell periiphery and regulation of cell polarization

S653-p - LLGL2 (human) ▲
Orthologous residues
LLGL2 (human): S653‑p, LLGL2 (mouse): S653‑p, LLGL2 (rat): S653‑p
Characterization
 Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (mouse) transfection of inactive enzyme, co-immunoprecipitation, phospho-antibody, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  localization to cell periiphery and regulation of cell polarization


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