Curated Information
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Curated Information Page
PubMed Id: 20045463 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lin L, et al. (2010) KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation. Mol Cell Neurosci 43, 315-25 20045463
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S552-p - Kv4.2 (human)
Orthologous residues
Kv4.2 (human): S552‑p, Kv4.2 (mouse): S552‑p, Kv4.2 (rat): S552‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial) [KCNIP4 (mouse), transfection], COS (fibroblast) [KCNIP4 (mouse), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
H-89 forskolin inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, protein stabilization
 Comments:  KCNIP4-mediated enhancement of channel surface expression


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