Curated Information
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Curated Information Page
PubMed Id: 11134016 
Xing HR, Kolesnick R (2001) Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J Biol Chem 276, 9733-41 11134016
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T269-p - RAF1 (human)
Orthologous residues
RAF1 (human): T269‑p, RAF1 (mouse): T269‑p, RAF1 (rat): T269‑p, RAF1 (chicken): T269‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE KSR (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y340-p - RAF1 (human)
Orthologous residues
RAF1 (human): Y340‑p, RAF1 (mouse): Y340‑p, RAF1 (rat): Y340‑p, RAF1 (chicken): Y340‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase

Y341-p - RAF1 (human)
Orthologous residues
RAF1 (human): Y341‑p, RAF1 (mouse): Y341‑p, RAF1 (rat): Y341‑p, RAF1 (chicken): Y341‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase


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