Curated Information
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Curated Information Page
PubMed Id: 20000467 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cimen H, et al. (2010) Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry 49, 304-11 20000467
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K179-ac - SDHA (mouse)
Orthologous residues
SDHA (human): K179‑ac, SDHA (mouse): K179‑ac, SDHA (rat): K171‑ac, SDHA (pig): K179‑ac
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry
 Relevant cell lines - cell types - tissues:  liver [SIRT3 (mouse), homozygous knockout]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
DEACETYLASE SIRT3 (mouse) genetic knockout/knockin of upstream enzyme

K485-ac - SDHA (mouse)
Orthologous residues
SDHA (human): K485‑ac, SDHA (mouse): K485‑ac, SDHA (rat): K477‑ac, SDHA (pig): K485‑ac
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry
 Relevant cell lines - cell types - tissues:  liver [SIRT3 (mouse), homozygous knockout]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
DEACETYLASE SIRT3 (mouse) genetic knockout/knockin of upstream enzyme

K498-ac - SDHA (mouse)
Orthologous residues
SDHA (human): K498‑ac, SDHA (mouse): K498‑ac, SDHA (rat): K490‑ac, SDHA (pig): K498‑ac
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry
 Relevant cell lines - cell types - tissues:  liver [SIRT3 (mouse), homozygous knockout]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
DEACETYLASE SIRT3 (mouse) genetic knockout/knockin of upstream enzyme

K538-ac - SDHA (mouse)
Orthologous residues
SDHA (human): K538‑ac, SDHA (mouse): K538‑ac, SDHA (rat): K530‑ac, SDHA (pig): K538‑ac
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry
 Relevant cell lines - cell types - tissues:  liver [SIRT3 (mouse), homozygous knockout]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
DEACETYLASE SIRT3 (mouse) genetic knockout/knockin of upstream enzyme


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