Curated Information

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PubMed Id: 16148943

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Koo SH, et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-11 16148943

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S133-p - CREB (mouse)

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Orthologous residues

CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: hepatocyte-liver

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
glucagon				increase
insulin				increase

S171-p - TORC2 (mouse)

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Orthologous residues

TORC2 (human): S171‑p, TORC2 (mouse): S171‑p, TORC2 (rat): S171‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: hepatocyte-liver

Cellular systems studied: primary cultured cells

Species studied: rat

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	AMPKA1 (rat)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Effect	Notes
glucagon			decrease
insulin			increase
glucagon			increase	initial decrease then maximal increase 2-3h
cycloheximide	glucagon		inhibit treatment-induced increase	Pretreatment with CHX blocked S171 phosphorylation.
	glucagon	SIK (human)	increase	Sik1 siRNA decreases
forskolin			decrease
AICAR			increase
forskolin	AICAR		decrease	some decrease

Downstream Regulation

Effect of modification (function): inhibition

Effect of modification (process): transcription, altered

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