Curated Information
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Curated Information Page
PubMed Id: 14976185 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Deval E, et al. (2004) ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem 279, 19531-9 14976185
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T40-p - ASIC3 (rat)
Orthologous residues
ASIC3 (human): S39‑p, ASIC3 iso2 (human): S39‑p, ASIC3 iso3 (human): S39‑p, ASIC3 (mouse): T40‑p, ASIC3 (rat): T40‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme, mutation in upstream enzyme recognition motif
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  channel activation

S523-p - ASIC3 (rat)
Orthologous residues
ASIC3 (human): S521‑p, ASIC3 iso2 (human): , ASIC3 iso3 (human): , ASIC3 (mouse): S520‑p, ASIC3 (rat): S523‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme, mutation in upstream enzyme recognition motif
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  channel activation


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