Curated Information
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Curated Information Page
PubMed Id: 11544179 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yamashita A, et al. (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev 15, 2215-28 11544179
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1084-p - RENT1 (human) ▲
Orthologous residues
RENT1 (human): S1084‑p, RENT1 (mouse): S1079‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE SMG1 (human)

S1089-p - RENT1 (human) ▲
Orthologous residues
RENT1 (human): S1089‑p, RENT1 (mouse): S1084‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE SMG1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE SMG1 (human) transfection of inactive enzyme, transfection of wild-type enzyme, mutation in upstream enzyme recognition motif

S1107-p - RENT1 (human) ▲
Orthologous residues
RENT1 (human): S1107‑p, RENT1 (mouse): S1102‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE SMG1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE SMG1 (human) transfection of inactive enzyme, transfection of wild-type enzyme, mutation in upstream enzyme recognition motif

S1127-p - RENT1 (human) ▲
Orthologous residues
RENT1 (human): S1127‑p, RENT1 (mouse): S1122‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE SMG1 (human)


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