Curated Information
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PubMed Id: 10945993 
Kronfeld I, et al. (2000) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem 275, 35491-8 10945993
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y155-p - PKCD (mouse)
Orthologous residues
PKCD (human): Y155‑p, PKCD (mouse): Y155‑p, PKCD iso2 (mouse): Y155‑p, PKCD (rat): Y155‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  C6 (glial)
 Cellular systems studied:  cell lines
 Species studied:  no information
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
PDGF increase
PP1 PDGF inhibit treatment-induced increase
PP2 PDGF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell cycle regulation
 Comments:  Mutation of Y155 to F caused enhanced proliferation in response to PMA.

Y187-p - PKCD (mouse)
Orthologous residues
PKCD (human): Y187‑p, PKCD (mouse): Y187‑p, PKCD iso2 (mouse): Y187‑p, PKCD (rat): Y187‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  C6 (glial)
 Cellular systems studied:  cell lines
 Species studied:  no information
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
PDGF increase
PP1 PDGF inhibit treatment-induced increase
PP2 PDGF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Fyn (mouse) Induces
 Comments:  Mutation of Y187 to F resulted in increased expression of glutamine synthetase.


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