Curated Information
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Curated Information Page
PubMed Id: 11350745 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Benes C, Soltoff SP (2001) Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases. Am J Physiol Cell Physiol 280, C1498-510 11350745
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T505-p - PKCD (rat)
Orthologous residues
PKCD (human): T507‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  parotid acinar-salivary gland
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester no change compared to control
LY294002, phorbol ester no change compared to control
rapamycin, phorbol ester no change compared to control
LY294002 no change compared to control
rapamycin no change compared to control
wortmannin no change compared to control
carbachol no change compared to control
carbachol no change compared to control
carbachol no change compared to control

S662-p - PKCD (rat)
Orthologous residues
PKCD (human): S664‑p, PKCD (mouse): S662‑p, PKCD iso2 (mouse): S688‑p, PKCD (rat): S662‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  parotid acinar-salivary gland
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
carbachol no change compared to control
carbachol no change compared to control
carbachol no change compared to control
phorbol ester no change compared to control
rapamycin, phorbol ester no change compared to control
LY294002, phorbol ester no change compared to control
wortmannin no change compared to control
rapamycin no change compared to control
LY294002 no change compared to control


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