Curated Information
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Curated Information Page
PubMed Id: 9305920 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li W, Zhang J, Bottaro DP, Pierce JH (1997) Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity. J Biol Chem 272, 24550-5 9305920
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S643-p - PKCD (mouse)
Orthologous residues
PKCD (human): S645‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  32D (myeloid) [IRS1 (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCD (mouse)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  PKC-delta phosphorylation mediates monocytic differentiation of 32D myeloid progenitor cells.


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