Curated Information
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Curated Information Page
PubMed Id: 19962314 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li J, Han YR, Plummer MR, Herrup K (2009) Cytoplasmic ATM in neurons modulates synaptic function. Curr Biol 19, 2091-6 19962314
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1987-p - ATM (mouse)
Orthologous residues
ATM (human): S1981‑p, ATM (mouse): S1987‑p, ATM (rat): S1988‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  N2a (neuron), neuron
 Cellular systems studied:  cell lines, primary cultured cells, tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase

S656-p - SYN1 iso3 (mouse)
Orthologous residues
SYN1 (human): S683‑p, SYN1 (mouse): S684‑p, SYN1 iso1 (mouse): , SYN1 iso3 (mouse): S656‑p, SYN1 (rat): S682‑p, SYN1 (cow): S684‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  N2a (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (mouse) siRNA inhibition of enzyme, modification site within consensus motif, co-immunoprecipitation, microscopy-colocalization

T35-p - VAMP2 (mouse)
Orthologous residues
VAMP2 (human): T35‑p, VAMP2 (mouse): T35‑p, VAMP2 (rat): T35‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  N2a (neuron)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (mouse) siRNA inhibition of enzyme, modification site within consensus motif, co-immunoprecipitation, microscopy-colocalization
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ATM (mouse) Induces molecular association, regulation co-immunoprecipitation
 Comments:  complex of ATM, VAMP2, ATR and SYN1


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