Curated Information
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Curated Information Page
PubMed Id: 17880897 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lubin FD, Sweatt JD (2007) The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 55, 942-57 17880897
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K6-a - H4 (human) ▲
Orthologous residues
H4 (human): K6‑a, H4 (mouse): K6‑a, H4 (rat): K6‑a, H4 (pig): K6‑a, H4 (cow): K6‑a
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning no change compared to control
DDTC no change compared to control

K9-a - H4 (human) ▲
Orthologous residues
H4 (human): K9‑a, H4 (mouse): K9‑a, H4 (rat): K9‑a, H4 (pig): K9‑a, H4 (cow): K9‑a
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning no change compared to control
DDTC no change compared to control

K13-a - H4 (human) ▲
Orthologous residues
H4 (human): K13‑a, H4 (mouse): K13‑a, H4 (rat): K13‑a, H4 (pig): K13‑a, H4 (cow): K13‑a
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning no change compared to control
DDTC no change compared to control

K17-a - H4 (human) ▲
Orthologous residues
H4 (human): K17‑a, H4 (mouse): K17‑a, H4 (rat): K17‑a, H4 (pig): K17‑a, H4 (cow): K17‑a
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning no change compared to control
DDTC no change compared to control

S180-p - IKK-alpha (human) ▲
Orthologous residues
IKK‑alpha (human): S180‑p, IKK‑alpha (mouse): S180‑p, IKK‑alpha (rat): S180‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning increase
DDTC contextual fear conditioning inhibit treatment-induced increase
DDTC no change compared to control
SSZ contextual fear conditioning inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered, transcription, altered

S11-p - H3 (rat) ▲
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning increase
DDTC contextual fear conditioning inhibit treatment-induced increase
DDTC no change compared to control
SSZ contextual fear conditioning inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered, transcription, altered

K15-a - H3 (rat) ▲
Orthologous residues
H3 (human): K15‑a, H3 (mouse): K15‑a, H3 iso2 (mouse): K15‑a, H3 iso3 (mouse): K15‑a, H3 (rat): K15‑a, H3 iso3 (rat): K15‑a, H3 (pig): K15‑a, H3 (chicken): K15‑a, H3 (cow): K15‑a
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning increase
DDTC contextual fear conditioning inhibit treatment-induced increase
DDTC no change compared to control
SSZ contextual fear conditioning inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered, transcription, altered

S181-p - IKK-beta (rat) ▲
Orthologous residues
IKK‑beta (human): S181‑p, IKK‑beta (mouse): S181‑p, IKK‑beta (rat): S181‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus'
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
contextual fear conditioning no change compared to control
DDTC no change compared to control


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