Curated Information

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Curated Information Page

PubMed Id: 7523122

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Rupp E, et al. (1994) A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. Eur J Biochem 225, 29-41 7523122

Y754-p - PDGFRa (human)

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Orthologous residues

PDGFRa (human): Y754‑p, PDGFRa (mouse): Y754‑p, PDGFRa (rat): Y753‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping

Relevant cell lines - cell types - tissues: AG1523 (fibroblast), PAE (endothelial)

Cellular systems studied: cell lines

Species studied: human, pig

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PDGFRb (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
PDGF				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Comments: a 134kDa and a 70kDa protein

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