Curated Information
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Curated Information Page
PubMed Id: 7523122 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rupp E, et al. (1994) A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. Eur J Biochem 225, 29-41 7523122
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Y754-p - PDGFRA (human)
Orthologous residues
PDGFRA (human): Y754‑p, PDGFRA (mouse): Y754‑p, PDGFRA (rat): Y753‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  AG1523 (fibroblast), PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Comments:  a 134kDa and a 70kDa protein


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