Curated Information
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Curated Information Page
PubMed Id: 17570479 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Linding R, et al. (2007) Systematic discovery of in vivo phosphorylation networks. Cell 129, 1415-26 17570479
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S531-p - BCLAF1 (human) ▲
Orthologous residues
BCLAF1 (human): S531‑p, BCLAF1 iso3 (human): S529‑p, BCLAF1 iso4 (human): S358‑p, BCLAF1 (mouse): S529‑p, BCLAF1 (rat): S531‑p, BCLAF1 iso3 (rat): S672‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, multiple reaction monitoring (MRM)
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) modification site within consensus motif
KINASE GSK3B (human) inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lithium decrease

S635-p - Rad50 (human) ▲
Orthologous residues
Rad50 (human): S635‑p, Rad50 (mouse): S635‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  GM02254 (lymphoblast)
 Cellular systems studied:  cell lines
 Species studied:  human

T690-p - Rad50 (human) ▲
Orthologous residues
Rad50 (human): T690‑p, Rad50 (mouse): T690‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  GM02254 (lymphoblast)
 Cellular systems studied:  cell lines
 Species studied:  human


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