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Orthologous residues
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p70S6K (human): T252‑p, p70S6K iso2 (human): T229‑p, p70S6K (mouse): T252‑p, p70S6K (rat): T252‑p, p70S6K iso2 (rat): T229‑p, p70S6K (fruit fly): T238‑p
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Characterization
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Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
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|
Relevant cell lines - cell types - tissues:
293 (epithelial)
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|
Cellular systems studied:
cell lines
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Species studied:
human
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Enzymes shown to modify site in vitro:
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|
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Upstream Regulation
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Potential in vivo enzymes for site:
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Type
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Enzyme
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Evidence
|
Notes
|
|
KINASE
|
PDK1 (human)
|
transfection of constitutively active enzyme, transfection of inactive enzyme
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|
|
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Downstream Regulation
|
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Effect of modification (function):
enzymatic activity, induced
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