|
Orthologous residues
|
|
HLA‑DRB1 (human): K227‑u, HLA‑DRB1 iso2 (human): K227‑u, HLA‑DRB1 iso3 (human): K227‑u, HLA‑DRB1 (mouse): K225‑u
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting
|
|
Disease tissue studied:
lymphoma, B cell lymphoma
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial), A20.2J (B lymphocyte)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
UBIQUITIN LIGASE
|
MARCH8 (human)
|
transfection of wild-type enzyme, transfection of inactive enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
protein degradation
|
|
Effect of modification (process):
endocytosis, altered
|
