Curated Information
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Curated Information Page
PubMed Id: 19933848 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Adon AM, et al. (2010) Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol 30, 694-710 19933848
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T198-p - NPM1 (mouse)
Orthologous residues
NPM1 (human): T199‑p, NPM1 iso2 (human): , NPM1 iso3 (human): T199‑p, NPM1 (mouse): T198‑p, NPM1 (rat): T198‑p, NPM1 iso2 (rat): T198‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-embryo [CDK2 (mouse), homozygous knockout], fibroblast-embryo [CDK4 (mouse), homozygous knockout], fibroblast-embryo [p53 (mouse), homozygous knockout]
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase wild-type
serum CDK4 (mouse) no change compared to control Cdk4 -/-
serum CDK2 (mouse) augment treatment-induced increase Cdk2 -/- decrease
CDK2 (mouse) increase Cdk2 -/- decrease
p53 (mouse) decrease p53-/- increase
CDK4 (mouse) no effect upon treatment-induced increase cdk4 -/- no effect
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  centrosome duplication


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