Curated Information

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Curated Information Page

PubMed Id: 19996295

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kim SS, et al. (2009) Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res 69, 9291-300 19996295

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S1152-p - BRCA1 (mouse)

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Orthologous residues

BRCA1 (human): S1189‑p, BRCA1 iso6 (human): ‑, BRCA1 (mouse): S1152‑p, BRCA1 (rat): S1153‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: mammary gland, skin

Cellular systems studied: tissue

Species studied: mouse

Comments: Brca1 S1152A/S1152A mutant mice

Downstream Regulation

Effect of modification (process): apoptosis, altered

Comments: required for proper skin structure and hair regeneration; confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for tumor prevention;

S122-p - ER-alpha (mouse)

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Orthologous residues

ER‑alpha (human): S118‑p, ER‑alpha (mouse): S122‑p, ER‑alpha (rat): S123‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: MEF (fibroblast)

Cellular systems studied: cell lines

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		BRCA1 (mouse)		increase	in BRCA1 S1152A mutant

S20-p - p53 (mouse)

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Orthologous residues

p53 (human): S20‑p, p53 (mouse): S20‑p, p53 iso2 (mouse): S23‑p, p53 (rat): S20‑p, p53 (rabbit): S20‑p, p53 (monkey): S20‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: MEF (fibroblast)

Cellular systems studied: cell lines

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase
	ionizing radiation	BRCA1 (mouse)		inhibit treatment-induced increase	delayed increase in BRCA1 S1152A mutant

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