Curated Information
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PubMed Id: 19996295 
Kim SS, et al. (2009) Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res 69, 9291-300 19996295
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1152-p - BRCA1 (mouse)
Orthologous residues
BRCA1 (human): S1189‑p, BRCA1 iso6 (human): , BRCA1 (mouse): S1152‑p, BRCA1 (rat): S1153‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  mammary gland, skin
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Brca1 S1152A/S1152A mutant mice
Downstream Regulation
 Effect of modification (process):  apoptosis, altered
 Comments:  required for proper skin structure and hair regeneration; confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for tumor prevention;

S122-p - ER-alpha (mouse)
Orthologous residues
ER‑alpha (human): S118‑p, ER‑alpha (mouse): S122‑p, ER‑alpha (rat): S123‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BRCA1 (mouse) increase in BRCA1 S1152A mutant

S20-p - p53 (mouse)
Orthologous residues
p53 (human): S20‑p, p53 (mouse): S20‑p, p53 iso2 (mouse): S23‑p, p53 (rat): S20‑p, p53 (rabbit): S20‑p, p53 (monkey): S20‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
ionizing radiation BRCA1 (mouse) inhibit treatment-induced increase delayed increase in BRCA1 S1152A mutant


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