|
Orthologous residues
|
|
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
neuron-'brain, hippocampus'
|
|
Cellular systems studied:
primary cultured cells
|
|
Species studied:
rat
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
isoproterenol
|
|
ADRB2 (rat)
|
|
increase
|
|
|
ICI-118,551
|
isoproterenol
|
|
ADRB2 (rat)
|
inhibit treatment-induced increase
|
|
|
peptide inhibitor
|
isoproterenol
|
|
ADRB2 (rat)
|
inhibit treatment-induced increase
|
peptides that interfere with ADRB2-GluR1 association (via PSD95)
|
|
forskolin
|
|
|
|
increase
|
|
|
