Curated Information
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Curated Information Page
PubMed Id: 20026641 
Palka-Hamblin HL, et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123, 236-45 20026641
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y64-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y64‑p, CTNNB1 (mouse): Y64‑p, CTNNB1 (rat): Y64‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), SW620 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Brk (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Brk (mouse) transfection of inactive enzyme, transfection of constitutively active enzyme

Y142-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y142‑p, CTNNB1 (mouse): Y142‑p, CTNNB1 (rat): Y142‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), SW620 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Brk (human)

Y331-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y331‑p, CTNNB1 (mouse): Y331‑p, CTNNB1 (rat): Y331‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), SW620 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Brk (human)

Y333-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y333‑p, CTNNB1 (mouse): Y333‑p, CTNNB1 (rat): Y333‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), SW620 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Brk (human)


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