Curated Information
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Curated Information Page
PubMed Id: 19996410 
Pecquet C, et al. (2010) Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. Blood 115, 1037-48 19996410
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y582-p - MPL (mouse)
Orthologous residues
MPL (human): Y591‑p, MPL (mouse): Y582‑p, MPL (rat): Y601‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [MPL (mouse), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  Mpl W515K/L mutant
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  cell growth, altered

Y616-p - MPL (mouse)
Orthologous residues
MPL (human): Y626‑p, MPL (mouse): Y616‑p, MPL (rat): Y635‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [MPL (mouse), transfection]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  Mpl W515K/L mutant
Downstream Regulation
 Effect of modification (function):  activity, induced
 Effect of modification (process):  cell growth, altered
Associated Diseases
Diseases: Alterations: Comments:
myeloproliferative disorder increased constitutive phosphorylation of this site in Mpl W515K/L mutant


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