Curated Information

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Curated Information Page

PubMed Id: 19996410

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Pecquet C, et al. (2010) Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. Blood 115, 1037-48 19996410

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y582-p - Mpl (mouse)

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Orthologous residues

Mpl (human): Y591‑p, Mpl (mouse): Y582‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry, mutation of modification site, western blotting

Relevant cell lines - cell types - tissues: BaF3 ('B lymphocyte, precursor') [Mpl (mouse), transfection]

Cellular systems studied: cell lines

Species studied: mouse

Comments: Mpl W515K/L mutant

Downstream Regulation

Effect of modification (function): inhibition

Effect of modification (process): cell growth, altered

Y616-p - Mpl (mouse)

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Orthologous residues

Mpl (human): Y626‑p, Mpl (mouse): Y616‑p