Curated Information
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Curated Information Page
PubMed Id: 20064390 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gu X, et al. (2009) Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron 64, 828-40 20064390
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S13-p - Huntingtin (human)
Orthologous residues
Huntingtin (human): S13‑p, Huntingtin (mouse): S13‑p, Huntingtin (rat): S6‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  BAC transgenic mice
Downstream Regulation
 Comments:  prevents huntingtin aggregation in vivo and in vitro
Associated Diseases
Diseases: Alterations: Comments:
Huntington's disease decreased

S16-p - Huntingtin (human)
Orthologous residues
Huntingtin (human): S16‑p, Huntingtin (mouse): S16‑p, Huntingtin (rat): S9‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  BAC transgenic mice
Downstream Regulation
 Comments:  prevents huntingtin aggregation in vivo and in vitro
Associated Diseases
Diseases: Alterations: Comments:
Huntington's disease decreased


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